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Revista médica de Chile

versão impressa ISSN 0034-9887

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CUCHACOVICH T, Miguel et al. Renal scleroderma crisis. Role of sclerodermic vasculopathy in the induction of cutaneous and visceral fibrosis.: Report of two cases. Rev. méd. Chile [online]. 2000, vol.128, n.1, pp.86-92. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872000000100012.

Although fibrosis and vasculopathy coexist in most patients with progressive systemic sclerosis, it is not clear if these events are the result of an unique etiologic factor or if one is consequence of the other. We report two cases of progressive systemic sclerosis that evolved to a renal scleroderma crisis. A 36 years old female presented with a Sjögren syndrome and painful subcutaneous nodules whose biopsy showed perivascular lymphocytic infiltration, perivascular thickening and normal skin. The ESR was 100 mm/h. She developed an hypertensive crisis and progressive renal failure, followed by a rapidly evolving progressive systemic sclerosis. The patient died in the course of this crisis. A 32 years old female with a progressive systemic sclerosis refractory to D-penicillamine treatment, receiving cyclosporin, presented a renal scleroderma crisis, that was successfully treated, with complete recovery of renal function. We highlight the different evolution of these cases, probably due to an early diagnosis and a better experience in the management of this condition. (Rev Méd Chile 2000; 128: 86-92)

Palavras-chave : Cyclosporin; Kidney failure, acute; Penicillamine; Scleroderma, systemic.

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