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vol.128 número4Distribución de los recursos financieros de acuerdo con la productividad (determinada por bibliometría) en los Laboratorios de Investigación Médica del Hospital de Clínicas, de la Facultad de Medicina de la Universidad de San Pablo (Brasil) índice de autoresíndice de assuntospesquisa de artigos
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Revista médica de Chile

versão impressa ISSN 0034-9887

Resumo

UAUY D, Ricardo; MARTINEZ A, Jessica I.  e  ROJAS B, Cecilia V.. Molecular nutrition. Rev. méd. Chile [online]. 2000, vol.128, n.4, pp.437-446. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872000000400012.

PPARs are transcription factors belonging to the super family of hormonal receptors. Their activity is regulated by fibrates, thiazolidinediones, certain anti inflammatory drugs and fatty acid derivatives, present in food. PPAR isoforms play a central role in lipid homeostasis, regulating anabolic (PPARg) and catabolic (PPARa) pathways of lipid metabolism. Additionally, these receptors participate in glucose homeostasis, influence cellular proliferation and differentiation and participate in inflammatory processes. The effects of PPARs on oxidative substrate partitioning suggests that they have a relevant role in the development of obesity and insulin resistance. (Rev Méd Chile 2000; 128: 437-46).

Palavras-chave : Diabetes mellitus; Lipid peroxidation; Obesity; Obesity in diabetes; Peroxisome proliferators.

        · texto em Espanhol

 

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