SciELO - Scientific Electronic Library Online

 
vol.128 número10Drogadicción embriofetal por abuso de pasta base de cocaína durante el embarazoSituación de Mepraia spinolai, vector silvestre de la enfermedad de Chagas en Chile, en relación con otros vectores desde la perspectiva de sus fuentes de alimentación índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Revista médica de Chile

versão impressa ISSN 0034-9887

Resumo

HERNANDEZ P, Glenn et al. Use of amphotericin B as lipid emulsions to decrease its toxicity in critical patients. Rev. méd. Chile [online]. 2000, vol.128, n.10, pp.1101-1107. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872000001000004.

Background: Amphotericin B is efficacious for the treatment of systemic candidiasis, however it has potentially serious toxic effects. Administration as lipid emulsions has been advocated to decrease its toxicity. Aim: To compare the safety and tolerance of amphotericin B administered as lipid emulsion or dissolved in dextrose in water. Patients and methods: Forty five patients with confirmed or highly suspected systemic candidiasis were studied. Between January 1996 and June 1997 amphotericin B was administered in dextrose in water to 17 patients (group 1). Between July 1997 and December 1998, the drug was delivered in lipid emulsions (Intralipid, group 2). Clinical and laboratory parameters (serum creatinine, urea nitrogen and potassium), were assessed daily. Results: Both treatment groups were clinically comparable and had the same survival. Accumulative amphotericin B dose administered was 343.2 ± 197 and 414.6 ± 518 mg respectively. Hypokalemia was more frequent in group 2 (52 and 25 % respectively, p < 0.05). There were no differences in the outcome of renal function or other adverse reactions. Conclusions: Administration of amphotericin B as lipid emulsions did not reduce its toxicity in critical patients (Rev Méd Chile 2000; 128: 1101-07)

Palavras-chave : Adverse effects; Amphotericin B; Antibiotics, antifungal; Drug toxicity.

        · texto em Espanhol

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons