SciELO - Scientific Electronic Library Online

vol.128 número10Mortalidad del adulto en ChileLa reforma de salud en Chile y el rol de las Facultades de Medicina: un intento de síntesis índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados


Revista médica de Chile

versão impressa ISSN 0034-9887


GONZALEZ C, Jorge. Phosphorylation in eukaryotic cells: Role of phosphatases and kinases in biology, pathogenesis and control of intracellular and bloodstream protozoa. Rev. méd. Chile [online]. 2000, vol.128, n.10, pp.1150-1160. ISSN 0034-9887.

Cells respond to environmental or cellular changes, rapidly switching protein activities from one state to another. In eukaryotes, a way to achieve these changes is through protein phosphorylation cycles, involving independent protein kinase and protein phosphatase activities. Current evidences show that phosphatases and kinases are also involved in the molecular basis of immune response and in diseases such as diabetes obesity and Alzheimer. In protozoan parasites like Trypanosoma and Leishmania, several kinases and phosphatases have been identified, many of them have been cloned but in several cases their biological role remains undetermined. In this review, the state-of-the art is summarized and the role of phosphatases and kinases in biological phenomena such as remodeling, invasion and pathogenic capacity of protozoan parasites is described. The real chance to use these components of signal transduction pathways as target for chemotherapeutic intervention is also discussed (Rev Méd Chile 2000; 128: 1150-60).

Palavras-chave : Leishmania; Phosphorylation; Phosphorylase kinase; Phosphorylase phosphatase; Protozoan infections; Trypanosoma.

        · texto em Espanhol


Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons