SciELO - Scientific Electronic Library Online

vol.128 número11Epidemiología molecular: El impacto de la biología molecular en la investigación epidemiológicaGenética de los desórdenes adictivos índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados


Revista médica de Chile

versão impressa ISSN 0034-9887


ROA S, Juan C et al. p53 tumor supresor gene in digestive cancer. Rev. méd. Chile [online]. 2000, vol.128, n.11, pp.1269-1278. ISSN 0034-9887.

Malignant diseases of the digestive tract cause more than 50% of deaths due to cancer in Chile. There is a high incidence of gastric and gallbladder cancer and an increasing frequency of colorectal cancer. P53 tumor suppressor gene has a great importance in carcinogenesis and its alterations are specially important in digestive tract tumors such as colorectal cancer. There is contradictory evidence about the frequency of p53 gene or protein alterations or their biological significance. There is little information about p53 in Chile and it is mostly limited to immunohistochemical studies. This revision analyzes the frequency of p53 alterations in digestive tract tumors in Chile, using immunohistochemical and molecular biology methods. A special emphasis is given to the prognostic importance of this gene (Rev Méd Chile 2000; 128: 1269-78)

Palavras-chave : Genes, p53; Genetic markers; Genetic predisposition to disease; Digestive system neoplasm.

        · texto em Espanhol


Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons