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Revista médica de Chile

versão impressa ISSN 0034-9887

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SALVADO G, Antonio et al. Early erythropoietin use for the prevention of anemia in very low birth weight newborns. Rev. méd. Chile [online]. 2000, vol.128, n.12, pp.1313-1317. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872000001200002.

Background: Anemia is common among very low birth weight newborns and requires frequent blood tranfusions. Erythropoietin was been reported to be useful in the prevention of this anemia. Aim: To asses the benefits of early (before the third week of life) Human recombinant Erythropoietin (r-EPO) administration to reduce the requirement of blood tranfusions in very low birth weight newborns. Patients and methods: sixty newborns under 1500g of birthweight were randomly assigned to recive r-EPO (n=29) or placebo (n=31) three times per week, during four weeks. Packed red cell volume and reticulocyte counts were measured weekly. Serum erythropoietin was measured prior to eigth dose. Transfusion requirements were recorded. Results: r-EPO reduced transfusions from 1.41 ± 1.1 to 0.69 ± 1 transfusions/newborns (p<0.001). At the fourth week of treatment, reticulocyte count was 14.8 ± 7 and 6.4 ± 4.9% in the active treatment group and placebo group respectively (p<0.001). Conclusions: r-EPO reduces the requrement of transfusions in low birth weight infants (Rev Méd Chile 2000; 128: 1313-17).

Palavras-chave : Anemia neonatal; Erythropoietin; Infant, low birth weight.

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