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Revista médica de Chile

versão impressa ISSN 0034-9887


FAVI C, Myriam et al. Immune response of suckling mouse brain (CRL) rabies vaccine and tissue culture rabies vaccine (Verorab®) in pre-exposure prophylaxis in humans. Rev. méd. Chile [online]. 2004, vol.132, n.1, pp.41-46. ISSN 0034-9887.

A WHO experts committee recommended the substitution of antirabic vaccines produced in nervous tissue, by vaccines produced in tissue cultures. Aim: To compare the immunogenic capacity of antirabic vaccines CRL (produced in nervous tissue) and Verorab® (produced in tissue culture), used for pre-exposure prophylaxis in humans. Patients and methods: Fifty four volunteers were immunized for this study. The first group, vaccinated with CLR was treated with a scheme of 4 subcutaneous peri umbilical doses in days 0, 3, 7 and 28. The second group, vaccinated with Verorab® vaccine was treated with a scheme of 3 intramuscular doses in deltoid zone at days 0, 7 and 28. Blood samples were obtained at days 0, 7, 42 and 365 to measure neutralizing antibodies using the Inhibition of Fluorescent Focus Technique (RFFIT). Results: At day seven, a primary non protective immunologic response was observed in both groups, with titers significantly higher in the group vaccinated with Verorab®. At day 42, no differences were observed. At day 365, all subjects vaccinated with Verorab® and 50% of individuals vaccinated with CRL had protective antibody titers (p <0,05). Conclusions: The vaccine produced in cell breeds (Verorab®) produces a better an faster immunologic response compared to the CRL vaccine (Rev Méd Chile 2004; 132: 41-6).

Palavras-chave : Antibodies; viral; Rabies vaccine; Vaccines.

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