SciELO - Scientific Electronic Library Online

 
vol.132 número3Costo-efectividad de la promoción de la salud en Chile: Experiencia del programa «¡Mírame!»Las Rickettsias del grupo de las fiebres manchadas: Respuesta inmune y sus proteínas inmunodominantes índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

Compartir


Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

KALERGIS P, Alexis M et al. Clinical applications of antigen-specific detection of T lymphocytes. Rev. méd. Chile [online]. 2004, vol.132, n.3, pp.371-380. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872004000300014.

The important role that T lymphocytes play during the immune response against pathogens and tumor cells has encouraged the development of technologies aimed to detect these immune cells in an antigen-specific fashion. Recently, a methodology consisting of the production of soluble ligands that bind the T lymphocyte receptor was developed. Such ligands consist of molecules from the Major Histocompatibility Complex loaded with either pathogen or tumor derived peptides. These molecular complexes are tetramerized to enhance the binding efficiency to the T cell receptor (TCR), which improves the detection sensitivity of antigen specific T lymphocytes. This new technology is currently used successfully during the follow up patients that were vaccinated against certain tumor antigens, to evaluate the expansion of tumor specific T lymphocytes. This methodology is also promising for the detection and specific deletion of autoreactive T lymphocytes as a treatment for autoimmune disorders. In this article we review the molecular components involved in antigen recognition by T lymphocytes, and the potential benefits for Biomedicine that could result from the detection of these cells by soluble specific ligands (Rev Méd Chile 2004; 132: 371-80).

Palabras clave : Histocompatibility antigens; Immunity, cellular; T Lymphocytes.

        · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons