SciELO - Scientific Electronic Library Online

 
vol.132 issue10A national birth weight distribution curve according to gestational age in Chile from 1993 to 2000Resistance to gentamicin, amikacin and ciprofloxacin among nosocomial isolates of Klebsiella pneumoniae subspecie pneumoniae producing extended spectrum ß-lactamases author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista médica de Chile

Print version ISSN 0034-9887

Abstract

DE LA MAZA C, M Pía et al. Weight maintenance in humans: Could it mimic calorie restriction of animal models?. Rev. méd. Chile [online]. 2004, vol.132, n.10, pp.1155-1172. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872004001000002.

Background: Energy restriction (ER) extends life span in animals, by decreasing oxidative stress. Aim: To compare adiposity, metabolic variables and DNA oxidative damage, among adults, reporting a constant body weight (weight maintainers), versus those reporting a progressive increase (weight gainers). Subjects and Methods: Clinical history, dietary recall, anthropometric measures, abdominal CT scan and fasting blood samples (to measure lipoproteins, glucose and insulin), were obtained in 44 males. These subjects were classified as weight maintainers if they had a change in weight of 3 kg or less in the last 10 years, or weight gainers, if they had a weight increment of more than 6 kg in the same lapse. Oxidative damage was assessed by 8-hydroxydeoxyguanosine (8-OHdG), in DNA extracted from circulating lymphocytes, in 5 weight maintainers, 8 weight gainers and 5 healthy elders. Results: Energy intake was 18% higher in weight gainers (p <0.01). Adiposity and central fat were higher among weight gainers (p <0.01). Abdominal fat correlated with serum lipoproteins, glucose and insulin sensitivity, assessed by the Homeostasis Model Assessment (HOMA). 8-OHdG levels did not differ between groups. Conclusions: The analysis of weight change based on the clinical history correlates with actual body composition, thus it may be a reliable indicator of long term energy intake. This method could be comparable to weight clamp models employed in animals to study aging (Rev Méd Chile 2004; 132: 1166-72)

Keywords : Body weight; Energy intake; Oxidative stress.

        · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License