SciELO - Scientific Electronic Library Online

 
vol.133 issue1Clinical, genetic and molecular features in 45 patients with Prader-Willi SyndromeOutcome of microbial invasion of amniotic cavity in the preterm premature rupture of membranes author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista médica de Chile

Print version ISSN 0034-9887

Abstract

SALDIAS P, Fernando et al. Antimicrobial susceptibility of Streptococcus pneumoniae in pediatric and adult population from Santiago, 1997-2003. Rev. méd. Chile [online]. 2005, vol.133, n.1, pp.42-49. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872005000100006.

Background: In Chile, the emergence of drug-resistant strains of Streptococcus pneumoniae has complicated treatment decisions and may lead to treatment failures. Aim: to examine antimicrobial resistance trends among pneumococcal isolates from the Catholic University Hospital between 1997 and 2003. Material and methods: During a seven-year period, we examined 901 strains of S. pneumoniae isolated from sterile and non-sterile samples from adult and pediatric population. Results: Overall, 20% of isolates showed intermediate resistance to penicillin (MIC: 0.12-1 µg/ml) y 10.8% high level of resistance to penicillin (MIC ³ 2 µg/ml). Pneumococcal resistance to penicillin did not change significantly during the study period, but it was more common in pediatric patients and isolates from non-sterile samples. No isolate had a MIC ³ 8 µg/ml for penicillin. Twenty one percent of pneumococcal strains were resistant to erythromycin, 41.6% to trimethoprim-sulfamethoxazole and 3.6% to chloramphenicol. Macrolides resistance tended to increase between 1997 and 2003. Fourteen percent of strains showed intermediate resistance (MIC: 1 µg/ml) and 2.5%, a high level of resistance to cefotaxime (MIC: ³ 2 µg/ml). No isolate had a CIM ³ 4 µg/ml for cefotaxime. Among those isolates with intermediate or high level of resistance to penicillin, there were significantly more isolates highly resistant to erythromycin, trimethoprim-sulfamethoxazole and cefotaxime. Conclusions: Multidrug-resistant pneumococci are common and are increasing in our country, particularly in pediatric population, probably associated to indiscriminate ambulatory prescription of antimicrobials (Rev Méd Chile 2005; 133: 42-49)

Keywords : Drug resistance, bacterial; Pneumococcal infections; Streptococcus pneumoniae.

        · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License