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Revista médica de Chile

versão impressa ISSN 0034-9887

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TRAIPE C, Leonidas et al. Markers of thrombophilia in patients with retinal vein thrombosis. Rev. méd. Chile [online]. 2005, vol.133, n.2, pp.167-174. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872005000200003.

Background: Thrombophilia is an alteration of hemostasis that increases the risk to venous or arterial thrombosis. This condition may be the underlying cause of retinal vein thrombosis. Aim: To study the presence of thrombophilia in patients with retinal vein thrombosis. Patients and methods: Prospective study of 55 patients aged 22 to 86 years, with retinal vein thrombosis (central or branch). Antithrombin III, coagulant protein C, functional protein S, resistance to activated C protein, homocysteine, prothrombin G20210A gene, lupus anticoagulant and anticardiolipin antibodies were measured in all. Results: Seventeen patients had thrombophilic markers (antiphospholipid syndrome in seven, hyperhomocysteinemia in six and resistance to protein C in three). Of these 17 patients, 53% had high blood pressure, 35% an abnormal serum lipid profile and 23% a personal history of thrombosis. The thrombosis was central in 12 (ischemic in four) and of a branch in five (ischemic in two). Conclusions: Thrombophilic markers must be assessed in patients with retinal vein thrombosis (Rev Méd Chile 2005; 133: 167-74)

Palavras-chave : Activated protein C resistance; Antiphospholipid syndrome; Retinal vein occlusion; Thrombophilia.

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