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Revista médica de Chile

versão impressa ISSN 0034-9887

Resumo

SABUGO S, Francisca et al. Rituximab (anti-CD20 monoclonal antibody) for refractory systemic lupus erythematosus: Report of one case. Rev. méd. Chile [online]. 2005, vol.133, n.6, pp.681-684. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872005000600010.

New therapeutic approaches that include depletion of B cells using rituximab, a chimeric monoclonal antibody directed against the B cell specific antigen CD-20 have been developed for the treatment of systemic lupus erythematosus (SLE). We report the case of a 18 years old girl with SLE that did not respond and experienced adverse effects with the use of hydroxycloroquine, methotrexate, mycophenolate mofetil, azathioprine and high-dose steroids. Rituximab was given weekly at 375 mg/m2 for four doses. The drug was well tolerated and the patient had no adverse reactions. She remains asymptomatic three months later

Palavras-chave : Lupus erythematosus, systemic; Monoclonal antibody CD20; Rituximab.

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