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Revista médica de Chile

versão impressa ISSN 0034-9887

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CORVALAN R, Alejandro et al. Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus. Rev. méd. Chile [online]. 2005, vol.133, n.7, pp.753-760. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872005000700001.

Background: Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. Aim: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. Material and methods: Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus. Results: Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57). Conclusions: Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr

Palavras-chave : Epstein-Barr virus infections; Herpes virus 4; human; Stomach neoplasms.

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