SciELO - Scientific Electronic Library Online

 
vol.134 número1Hidrotórax agudo masivo secundario a diálisis peritoneal aguda en síndrome hemolítico urémico: Caso clínicoLa exposición prenatal a andrógenos como factor de reprogramación fetal índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Revista médica de Chile

versão impressa ISSN 0034-9887

Resumo

TAPIA S, Alexis  e  ARAYA M., Magdalena. Oxidative stress, prooxidants and Crohn disease. Rev. méd. Chile [online]. 2006, vol.134, n.1, pp.95-100. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872006000100014.

The frequency of Crohn disease shows a significant increase in the last century. Affected patients show a misbalance between production of free radicals and anti oxidant defenses. Thus, one of the increasingly accepted htypotheses to explain the origin of this disease, is the oxidative stress that occurs in the intestinal mucosa. Dietary factors including self administered vitamin and mineral supplemets may play a role, especially when they contain excessive amounts of iron and copper, known for their prooxidant capacities. Unfortunately, little is known about how these metals may influence the antioxidant defenses in the intestinal mucosa. This article reviews the literature on the why and how these elements may act on individuals susceptible to develop Crohm disease, including the evidence supporting the hypothesis that oxidative stress in the intestinal mucosa is an important pathogenetic factor

Palavras-chave : Crohn disease; Inflammatory bowel diseases; Oxidative stress; Reactive oxygen species.

        · texto em Espanhol     · Espanhol ( pdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons