SciELO - Scientific Electronic Library Online

 
vol.134 número4Hierro, oxígeno y desarrollo placentario en la génesis de la preeclampsia: Efectos de la altura en EcuadorLos Comités de de Ética Asistencial y las repercusiones jurídicas de sus informes índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

Compartir


Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

QUINONES, Luis et al. Cancer pharmacogenetics: Study of genetically determined variations on cancer susceptibility due to xenobiotic exposure. Rev. méd. Chile [online]. 2006, vol.134, n.4, pp.499-515. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872006000400015.

Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development of non-invasive molecular techniques that identify genetic variants in human beings. There is also a need to explain the individual differences in susceptibility to drug actions and disease risk. Genetic variants can modify the magnitude of a pharmacologic effect, toxicity threshold, secondary effects and drug interactions. There are approximately thirty families of drug-metabolizing enzymes with genetic variants that cause functional alterations and variations in pharmacologic activity. We summarize the general knowledge about genetic variants of biotransformation enzymes, their relationship with cancer risk and the role of ethnicity. Cancer pharmacogenetics is another promising and exciting research area that will explain why people with an almost identical group of genes, have a different susceptibility to cancer, whose etiology has genetic and environmental components

Palabras clave : Neoplastic processes; Pharmacogenetics; Toxicogenetics; Xenobiotics.

        · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons