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Revista médica de Chile

Print version ISSN 0034-9887

Abstract

GUZMAN G, Pablo et al. Immunohistochemical expression of the E-cadherin-catenin complex in gastric cancer. Rev. méd. Chile [online]. 2006, vol.134, n.8, pp.1002-1009. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872006000800009.

Background: The E-cadherin/catenin complex plays an essential role in the control of epithelial differentiation. Abnormal expression in tumors correlates with histological grade, advanced stage and poor prognosis. Aim: To evaluate the expression pattern of E-cadherin/catenin complex in gastric carcinoma and analyze their association with tumor clinicopathological features and patient survival. Material and Methods: Inmunohistochemical staining of E-cadherin, a and ß-catenin was performed from paraffin specimens of 65 gastric carcinomas. Results: Abnormal expression of E-cadherin, a and ß-catenin was demonstrated in 82%, 85% and 88% of gastric carcinomas, respectively. There was a significant correlation between abnormal expression and Lauren pathological classification and depth of infiltration, but not with tumor stage, positive lymph node metastases and survival. Conclusion: Abnormal expression of E-cadherin, a and ß-catenin occurs frequently in gastric carcinoma and correlates with histological grade (Rev Méd Chile 2006; 134: 1002-9).

Keywords : Alpha catenin; Beta catenin; E-cadherin; Stomach neoplasms.

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