SciELO - Scientific Electronic Library Online

 
vol.134 issue11Prognostic factors and outcome of community-acquired pneumonia in hospitalized adult patientsSplit night polysomnography to titrate continuous positive airway pressure therapy in adult patients with obstructive sleep apnea author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista médica de Chile

Print version ISSN 0034-9887

Abstract

ARTIGAS A, Carmen Gloria et al. Frequency of TEL/AML1 and BCR/ABL fusion genes in children with acute lymphoblastic leukemia. Rev. méd. Chile [online]. 2006, vol.134, n.11, pp.1367-1376. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872006001100003.

Background: t(12;21) (p12;q22) and t(9;22) (q34;q11) translocations have prognostic significance in acute lymphoblastic leukemia (ALL). The fusion genes TEL/AML1 y BCR/ABL, generated by these translocations, can be easily detected using molecular biology technique. Aim: To study the frequency of TEL/AML1 y BCR/ABL fusion genes in children with ALL. Material and methods: Fifity six children with ALL (age range 1 month- 14 years) were studied, thirty eight from our Temuco Hospital and 18 from the Metropolitan Region. TEL/AML1 y BCR/ABL fusion genes were detected in bone marrow samples using a reverse transcriptase nested polymerase chain reaction (RT-PCR). Results: TEL/AML 1 and BCR/ABL fusion gene transcripts were detected in 13 (23%) and 2 (4%) children, respectively. No differences in survival were observed between children with positive or negative transcripts for TEL/AML1 fusion gene. However, those positive for BCR/ABL fusion gene, had a significantly lower survival. Conclusions: The frequency of TEL/AML1 and BCR/ABL fusion gene transcripts in these children with ALL is similar to that described by other authors

Keywords : Fusion proteins, BCR-ABL; Leukemia, lymphocytic, acute; TEL-AML1 fusion protein.

        · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License