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Revista médica de Chile

versão impressa ISSN 0034-9887

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MENNICKENT C, Sigrid; VEGA H, Mario; GODOY M, Carmen Gloria  e  LEON H, M. Doris. Saliva and plasma levels of carbamazepine have a poor correlation: a pilot study. Rev. méd. Chile [online]. 2007, vol.135, n.3, pp.335-340. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872007000300008.

Abstract: Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect. There is not a good relationship between the dose of the carbamazepine and their effects in humans, but the effects of this drug have been well correlated with its plasma levels. Aim: To measure the correlation between plasma and saliva levels of carbamazepine in children with epilepsy. Material and Methods: Saliva and plasma levels of carbamazepine were measured by using instrumental planar chromatography in 11 epileptic children aged 8 to 15 years treated with the drug for at least six months. Results: The mean saliva/plasma ratio was 0.18±0.05 and the mean of carbamazepine concentration in saliva, expressed as a percentage of concentrations in plasma, was 17.97±5.40. There was a poor linear correlation (r =0.37) between the concentrations of carbamazepine in both fluids. Conclusions: In this group of epileptic children the correlation between saliva and plasma carbamazepine levels was weak

Palavras-chave : Carbamazepine; Epilepsy; Saliva.

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