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Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

ROJAS, Elsa Marina et al. Association between glutathione peroxidase levels and clinical manifestations of dengue. Rev. méd. Chile [online]. 2007, vol.135, n.6, pp.743-750. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872007000600008.

Background: Glutathione peroxidase (GP) can be used as a marker of oxidative stress in infectious diseases. Aim: To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue. Patients and Methods: Between April 2003 and December 2004, 161 patients with dengue were prospectively evaluated. In the first evaluation, within 48 and 96 hours of disease onset, a plasma sample was obtained to measure the GP levels. The association between GP levels, clinical manifestations and complications was evaluated during the follow up. Results: Mean GP values were 1198 U/L (95% confidence interval 1089-1306). Values greater than 1200 U/L were associated with headache, arthralgias and increased heart rate. There was a negative association between GP levels and serum triglycerides. During follow up, patients with GP >1200 U/L had a higher frequency of spontaneous hemorrhages. In a logistic regression analysis arthralgias, fever and increased heart rate, were independently associated with levels >1200 U/L. Conclusions: GP levels was associated to some of the manifestations of dengue. This finding suggests that the intensity of oxidative stress can influence the clinical presentation of dengue

Palabras clave : Arthralgia; Dengue; Fever; Glutathione peroxidase.

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