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Revista médica de Chile

versão impressa ISSN 0034-9887

Resumo

TRONCOSO SEN, Mónica; ROJAS H, Carla  e  BRAVO C, Eduardo. Isotretinoin embryophaty: Report of one case. Rev. méd. Chile [online]. 2008, vol.136, n.6, pp.763-766. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872008000600012.

Retinoic acid is a widely used drug in the treatment of cystic acné. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months of female whose mother was exposed to retinoic acid in both pregestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms ofthe teratogenic effeets of retinoic acid

Palavras-chave : Abnormalities, drug-induced; Embryonic and fetal development; Tretinoin.

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