SciELO - Scientific Electronic Library Online

 
vol.137 issue2Thiopurine S-methyltransferase gene polymorphism in Chilean blood donorsHealth related quality of life among patients on chronic hemodialysis author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista médica de Chile

Print version ISSN 0034-9887

Abstract

ARTEAGA, Antonio; POLLAK, Felipe; ROBRES, Leonor  and  VELASCO, Nicolás. Clinical and metabolic features of subjects with glucose intolerance and high fasting glucose levels. Rev. méd. Chile [online]. 2009, vol.137, n.2, pp.193-199. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872009000200002.

Background: Subjects with glucose intolerance or high fasting glucose levels have a higher cardiovascular rísk and frequently become diabetic. Aim: To assess clinical and metabolic characteristics of patients with glucose intolerance or high fasting glucose levels. Material and methods: Fasting and post glucose load serum glucose and insulin levels were measured in 1404 people, aged 42,0 ± 14,2 years (81% women) with high diabetic rísk. We categorízed subjects in different alterations of blood glucose, according to 2006 Amerícan Diabetes Association categoríes. Insulin resistance (RI), insulin secretion (B %) and insulin disposition (ID), were calculated using fasting blood glucose and insulin levels, using the homeostasis model assessment (HOMA I and II). Results: Sixty percent of studied subjects had first grade relatives with diabetes mellitus and 1097 (78%) were categorízed as normal (N), 45 (3%) as Diabetes Mellitus (DM), 161 (11%) as high fasting glucose levels (GAA) and 103 (7%) as glucose intolerant (ITG). Fifty three of the 106 subjects with GAA (50%), were also glucose intolerant. Subjects with GAA had similar insulin sensitivity and lower B cell function than N (insulin disposition 58 ± 12 and 111 ± 32%, respectively p <0.01). ITG had less insulin sensitivity than N (HOMA-IR 2.6 ± 1.50 ± and 2.0 ± 1.30, respectively) and only a mild decrease in B cell function (insulin disposition 96 ± 26 and 111 ± 32% respectively, p < 0.01). Patients GAA plus ITG had similar alterations than those with DM (HOMA-IR 3.8 ± 2.2 and 4.4 ± 3.7respectively; insulin disposition 57 ± 10 and 56.0 ± 26% respectively. Conclusions: Patients with higher fasting glucose levels behave differently from those with glucose intolerance. High fasting glucose levels are highly prevalent in subjects with high rísk of DM and must be considered as rísk indicator in preventive programs for diabetes mellitus.

Keywords : Glucose intolerance; Insulin; Insulin resistance.

        · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License