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Revista médica de Chile

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HERRERA R, Cristian  and  ARAVENA L, Carlos. Critically appraised article: Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: A metaanalyses. Rev. méd. Chile [online]. 2009, vol.137, n.2, pp.308-311. ISSN 0034-9887.

Background: Conventional tests are not always helpful in making a diagnosis of tuberculous pleurisy. Many studies have investigated the usefulness of adenosine deaminase (ADA) in pleural fluid for the early diagnosis of tuberculous pleuresy. We conducted a metaanalysis to determine the accuracy of ADA measurements in the diagnosis of tuberculous pleurisy. Methods: After a systematic review of English ¡anguage studies, sensitivity, speciñcity and other measures of accuracy of ADA concentration in the diagnosis of pleural effusion were pooled using random effects models. Summary receiver operating characteristic curves were used to summarize overall test performance. Results: Sixty-three studies met our inclusión criteria. The summary estimates for ADA in the diagnosis of tuberculous pleurisy in the studies included were sensitivity 0.92 (95% confidence interval 0.90-0.93), speciñcity 0.90 (95% confidence interval 0.89-0.91), positive likelihood ratio 9.03 (95% confidence interval 7.19-11.35), negative likelihood ratio 0.10 (95% confidence interval 0.07-0.14), and diagnostic odds ratio 110.08 (95% confidence interval 69.96-173.20). Conclusions: ADA determination is a relative sensitive and speciñc test for the diagnosis of tuberculous pleurisy. Measurement of ADA in pleural effusion is thus likely to be a useful diagnostic tool for tuberculous plerisy. The results of ADA assays should be interpreted in parallel with clinical findings and the results of conventional tests

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