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Revista médica de Chile

versão impressa ISSN 0034-9887

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IRARRAZAVAL O, MARÍA ELISA. Antagonism of tamoxifen and antidepressants among women with breast cancer. Rev. méd. Chile [online]. 2011, vol.139, n.1, pp.89-99. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872011000100013.

Tamoxifen is used as an adjuvant therapy to reduce breast cáncer recurrence among women with estrogenreceptor positive tumors. Antidepressants are also com-monly used in such women, to treat depression or to manage hotflush.es, afrequent tamoxifen secondary effect. Some antidepressants couldpotentially inhibit cytochrome P450 2D6, required to actívate tamoxifen, interfering with its action. Although there is not a clear cut directive on the subject, it is nowadays recommended to treat women with antidepressants with the lower cytochrome P450 2D6 inhibition potential to avoid apossible antagonism that may reduce tamoxifen s prevention of breast cáncer recurrence at least in some patients with CYP2D6 genetic variation. The recommended antidepressants are desvenlafaxine, milnacipran, venlafaxin, escitalopram and citalopram.

Palavras-chave : Antidepressive agents; Breast neoplasms; Tamoxifen.

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