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Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

LEVICAN, JORGE et al. Parvovirus B19 among blood donors from three hospitals in Santiago, Chile. Rev. méd. Chile [online]. 2011, vol.139, n.2, pp.143-149. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872011000200001.

Background: Parvovirus B19 (B19) is associated with a wide range of diseases in humans, whose severity depends on the immunological and hematological status of the host. It is transmitted mainly through the airway but also by transfusions. Aim: To determine the B19 DNA carrier frequency in a population of volunteer blood donors from three hospitals blood banks in Santiago, Chile, and to determine the viral load in DNA positive cases. Material and Methods: A total of477 serum samples were analyzed. The screening of B19 DNA was carried out by nested polymerase chain reaction (PCR) directed to the non-structural region of the virus (NS1). The viral load in positives cases was quantified by NS1 Real Time PCR. Results: Parvovirus B19 was detected in four samples, rendering a frequency of 1:119. The viral loads ranged from less than 2000 to 5,626 x 105 genome equivalents/ml. Conclusions: Parvovirus B19 was present in four of 477 blood bank blood donors from three hospitals in Santiago.

Palabras clave : Blood banks; Genome, human; Parvovirus B19, human.

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