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Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

MARTINEZ B, David; GUERRERO T, Rodrigo; GRANDJEAN B, Marcela  y  CARTIER R, Luis. Limbic encephalitis with positive anti-N-methyl-D-aspartate antibodies. Rev. méd. Chile [online]. 2012, vol.140, n.9, pp.1170-1173. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872012000900010.

Background: Limbic encephalitis is a subacute syndrome characterized by memory impairment, confusion, seizures, hypothalamic dysfunction and psychiatric symptoms. It has been associated to tumors located outside of the central nervous system. In 2007, anti-N-methyl-D-aspartate receptors (NMDAr) antibodies were found in serum and CSF of patients with this particular type of encephalitis. We report a 25-year-old female who, following upper respiratory tract symptoms, developed serious behavioral and consciousness impairment that progressed to coma. Cerebrospinal fluid (CSF) analysis showed a lymphocyte pleocytosis, the electroencephalogram was altered with a slow encephalopathic rhythm and a brain magnetic resonance imaging was normal. Infectious etiologies were ruled out. CSF and serum anti NMDA receptors antibodies were positive.

Palabras clave : Limbic encephalitis; Nervous system; Paraneoplastic syndromes; Receptors; N-methyl-D-aspartate.

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