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Revista médica de Chile

versão impressa ISSN 0034-9887

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GONZALEZ JIMENEZ, Emilio; GARCIA LOPEZ, Pedro A; SCHMIDT-RIO-VALLE, Jacqueline  e  VALENZA, Carmen. Influence of nutritional status, hormones serum levels, and family history on breast cancer development. Rev. méd. Chile [online]. 2012, vol.140, n.10, pp.1263-1267. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872012001000004.

Background: Several studies have analyzed the relation between obesity and the hormonal imbalances generated by overweight and a family history of breast cancer. All of these factors are potentially implicated in the early development of breast cancer. Aim: To verify the existence of a significant relation between the nutritional status of breast cancer patients, their hormone serum levels (estrogens, prolactin, and progesterone), and the existence of a family history of breast cancer. Material and Methods: Retrospective data was collected from clinical records of524 women diagnosed with breast cancer in a Spanish hospital. Results: There was a positive association between estrogen, progesterone and prolactin serum levels and body mass index. The elevations in hormone levels occurred earlier in life among women with a family history of breast cancer. A two way ANOVA found a significant association between progesterone and prolactin levels with the age at diagnosis of breast cancer. Conclusions: Extreme serum levels of these hormones appear to be related to the early development of breast cancer, which in turn is influenced by the existence of a family history of cancer among those women with normal or average hormone levels.

Palavras-chave : Breast neoplasms; Menarche; Obesity.

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