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Revista médica de Chile

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BELLO, Cristina; MONDACA-CORNEJO, Luis; NAVARRETE-DECHENT, Cristian  and  GONZALEZ, Sergio. Cutaneous pemphigus vulgaris: A case report. Rev. méd. Chile [online]. 2013, vol.141, n.4, pp.525-530. ISSN 0034-9887.

Pemphigus is an autoimmune bullous disease that involves skin and mucous membranes caused by autoantibodies against antigens on the surface of keratinocytes. We report a 30-year-old male presenting with a five months history of pruriginous alopecic and crusted lesions in the scalp, that extended posteriorly to the trunk and limbs. Mucous membranes were not involved. A skin biopsy was performed, showing extensive loss of epidermis and acantholysis. Immuno fluorescence was positive for C3 and intercellular and epidermic IgG. With the presumptive diagnosis of pemphigus vulgaris (PV) without mucous involvement, the patient was treated with prednisone, observing an excellent clinical response. There are only few cases published in the literature of PV without mucous involvement. Some authors refer to this subtype of PV as "Cutaneous pemphigus vulgaris".

Keywords : Acantholysis; Desmogleins; Pemphigus.

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