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Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

DIAZ, Patricia V et al. Levels of inflammatory cytokines and plasma cortisol in respiratory syncytial virus bronchiolitis. Rev. méd. Chile [online]. 2013, vol.141, n.5, pp.574-581. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872013000500004.

Background: An increased inflammatory innate response may play a role in pathogenesis of respiratory syncytial virus (RSV) infection. Aim: To quantify pro-inflammatory cytokines (IL-6-IL-8, ÍL-2-P and TNF-a) in nasopharyngeal aspirate (NPA) and plasma, and plasma cortisol in previously healthy infants with RSV bronchiolitis. Patients  and Methods: We studied 49 infants aged less than one year of age with RSV bronchiolitis and 25 healthy controls. Severity was defined using a previously described modified score. We quantified interleukins in NPA and plasma by flow cytometry and plasma cortisol by radioimmunoanalysis. Results: Among patients with RSV bronchiolitis, 25 were classified as severe and 24 as moderate or mild. Significantly higher levels ofIL-6 and IL-8 in NPA and plasma and IL-lfi in NPA were found in children classified as severe, when compared to those with moderate or mild disease and controls. There was a positive correlation between IL-6 and cortisol in plasma (r = 0,55; p < 0,0001) and both were correlated with the severity of the disease. Conclusions: RSV bronchiolitis severity was associated with higher levéis of inflammatory interleukins and plasma cortisol.

Palabras clave : Bronchiolitis, viral; Interleukins; Respiratory syncytial virus infection.

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