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Revista médica de Chile

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VILLARROEL H, Pía; ARREDONDO O, Miguel  and  OLIVARES G, Manuel. Hepcidin as a central mediator of anemia of chronic diseases associated with obesity. Rev. méd. Chile [online]. 2013, vol.141, n.7, pp.887-894. ISSN 0034-9887.

Recent evidence suggests that obesity-related inflammation may play a central role in hepcidin regulation. Hepcidin is a key regulator ofiron homeostasis and has now been suggested as a central mediator ofiron metabolism disorders involved in the pathogenesis of anemia of chronic disease. In this review, we focus on subclinical inflammation in obesity and its effect on hepcidin levels, as the most plausible explanation for the relationship between anemia of chronic disease and obesity.

Keywords : Anemia, refractory; Antimicrobial cationic peptides; Chronic disease; Obesity.

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