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Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

URIBE S.M, Reinaldo; SUAREZ H, Felipe; SANDOVAL R, Patricio  y  MELLADO T, Patricio. Anti-GQ1b syndrome: Report of four cases. Rev. méd. Chile [online]. 2013, vol.141, n.9, pp.1211-1215. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872013000900016.

Anti-GQ1b syndrome includes Miller Fisher Syndrome (MFS), Guillain Barré Syndrome (GBS), Bickerstaff`s brain stem encephalitis (BBE) and Acute Ophtamoplegia (AO). We report four patients aged 16 to 76 years, with anti-GQ1b syndrome. All presented with MFS, one of them evolved to GBS pharyngeal-cervical-brachial variant and other to GBS with BBE. All had a previous history of diarrhea or upper respiratory tract infection. All had positive anti-GQ1b serum antibodies. Both brain magnetic resonance imaging and cerebrospinal fluid analysis were normal. Electrophysiology studies were compatible with a demyelinating disease. Two patients needed airway protection with an orotracheal tube and developed dysautonomia. All four patients were treated with immunomodulation. On the sixth month follow-up, patients had only minimal alterations in the neurological examination.

Palabras clave : Encephalitis; Gangliosides; Guillain Barré syndrome; Miller Fisher syndrome; Ophthalmoplegia.

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