SciELO - Scientific Electronic Library Online

 
vol.142 número3Mortalidad por suicidio en Chile: tendencias en los años 1998-2011Desarrollo y validación de un algoritmo para predecir riesgo de depresión en consultantes de atención primaria en Chile índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

BENEDETTO E, Juana; MOLGO N, Montserrat  y  GONZALEZ B, Sergio. Detection of HTLV-1 DNA in biopsies of Chilean patients with cutaneous T-cell lymphoma. Rev. méd. Chile [online]. 2014, vol.142, n.3, pp.314-322. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872014000300005.

Background: Human T-lymphotropic virus-1 (HTLV-1) infection has been associated with the pathogenesis of cutaneous T cell lymphomas (CTCL). Aim: To search for HTLV-1 DNA in skin biopsies of patients with CTCL. Material and Methods: A retrospective study was conducted using 25 biopsies of patients with CTCL. DNA was extracted from lymphoid tissue by microdissection. A nested PCR was conducted to detect HTLV-1 genome using primers for the tax region. As negative controls, four cases of superficial perivascular dermatitis were chosen. As positive controls, five cases of T-cell leukemia/lymphoma (ATCL) were studied. Results: A positive reaction was found in 3 of 25 cases. These biopsies corresponded to a case of Mycosis Fungoides, a case of CD30 (-) T-cell lymphoma and a case of lymphomatoid papulosis. Search was negative in the four cases of superficial perivascular dermatitis and positive in four cases of adult T-cell leukemia/lymphoma (ATCL). Conclusions: HTLV-1 DNA search in tissues is a useful tool recommended to study T-cell lymphomas. HTLV-1 infection only occurs in sporadic cases but may contribute to tumor aggressiveness and prognosis.

Palabras clave : Human T-lymphotropic virus 1; Lymphoma; T-cell; cutaneous; Polymerase chain reaction.

        · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons