SciELO - Scientific Electronic Library Online

 
vol.142 número6Asociación entre obesidad abdominal y daño oxidativo seminal en pacientes con síndrome metabólicoCompromiso multisistémico en apnea obstructiva del sueño índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Revista médica de Chile

versão impressa ISSN 0034-9887

Resumo

GOLDENBERG, Denisse; SANTOS, José Luis; HODGSON, María Isabel  e  CORTES, Víctor A. Novel physiological and therapeutic implications of leptin. Rev. méd. Chile [online]. 2014, vol.142, n.6, pp.738-747. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872014000600008.

The adipose tissue is an endocrine organ that produces a variety of protein hormones. One of them is leptin, which regulates several critical functions at the central nervous system such as caloric intake, basal energy expenditure, reproduction, glucose and lipid metabolism and osteogenesis. Acting at a local level, leptin modulates the immune system and promotes liver fibrogenesis. The most promising therapeutic implications of leptin will possibly be in type 1 diabetes mellitus (DM1). Its supplementation in animal models of DM1 prevents hyperglycemia and ketoacidosis. These actions depend on the activation of leptin receptors in the central nervous system and the suppression of glucagon signaling in the liver.

Palavras-chave : Diabetes mellitus; Leptin; Lipodystrophy; Obesity.

        · texto em Espanhol     · Espanhol ( pdf )