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Revista médica de Chile

versão impressa ISSN 0034-9887

Resumo

SANCHEZ, Ignacio et al. Assessment of an active pharmacovigilance system carried out by a pharmacist. Rev. méd. Chile [online]. 2014, vol.142, n.8, pp.998-1005. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872014000800007.

Background: Despite the importance of notifying and preventing adverse drug reactions (ADRs), they are under reported and their consequences are not adequately evaluated. Aim: To assess the impact of a pharmacovigilance system carried out by a pharmacist. Material and Methods: In an internal medicine service, the spontaneous report of ADRs was compared blindly with an active pharmacovigilance system in which a pharmacist detected, monitored and prevented ADRs. Results: A total of 1,196 patients was included. Of these 604 were hospitalized in intervened wards, where 50 suspected ADRs in 47 patients were reported. In non-intervened wards, only three ADRs were spontaneously reported. Therefore, the pharmacovigilance system significantly improved the detection and report of ADRs with a risk ratio of 15.4 (95% confidence intervals 4.8-49.1). Sixty six percent of ADRs were classified as severe. Antimicrobials were the main group of medications causing ADRs in 44% of reports. Forty three percent of ADRs were preventable and prolonged hospital stay by a mean of eight days. Conclusions: An active pharmacovigilance system carried out by pharmacists improves the detection of ADRs and promotes its prevention.

Palavras-chave : Drug-related side effects and adverse reactions; Pharmacists; Pharmoacovigilance.

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