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Revista médica de Chile

versão impressa ISSN 0034-9887

Resumo

RODRIGUEZ, Graciela Rita et al. Serum anti endomysial and anti transglutaminase antibodies in patients with connective tissue diseases. Rev. méd. Chile [online]. 2014, vol.142, n.12, pp.1510-1516. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872014001200003.

Background: The detection of anti-transglutaminase IgA (tTG) and anti-endomysial (EMA) is used for screening of celiac disease (CD) with a sensitivity and specificity of 90 and 99% respectively. There is an association between CD and connective tissue diseases (CTD). Aim: To report the frequency of IgA tTG and EMA in patients with a definite diagnosis of CTD and inflammatory arthropathies (IA). Material and Methods: One hundred forty nine patients, aged 19 to 86 years (133 females) with CTD and IA were studied. tTG were determined by ELISA and EMA by indirect immunofluorescence. Results: Eight participants had at least one positive antibody (5.4%, confidence intervals (CI) = 1.8-9), six had both (4.0% CI = 0.9-7.2) and two had only tTG positive. An intestinal biopsy was performed in four of these participants, finding a marked villous atrophy in three and partial atrophy in one. Conclusions: Five percent of this group of patients with CTD or IA had positive antibodies for CD.

Palavras-chave : Autoimmunity; Celiac disease; Connective Tissue Diseases; Rheumatic Diseases.

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