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Revista médica de Chile

Print version ISSN 0034-9887

Abstract

PULGAR-ALARCON, Iván; FUENTES-GUAJARDO, Macarena; LLOP, Elena  and  ROTHHAMMER, Francisco. Amerindian admixture estimation based on serological and molecular methods. Rev. méd. Chile [online]. 2015, vol.143, n.4, pp.439-443. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872015000400004.

Background: Amerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls. Aim: To compare Amerindian admixture estimates obtained using ABO*A and ABO*O blood group alleles and ancestral identity markers (AIMs) in the mixed Chilean population. Subjects and Methods: Amerindian admixture rates were determined in 720 Chilean volunteers residing in Arica and born in the 15 regions of the country, using ABO*O and ABO*A alleles and 40 AIMs selected from more than 500,000 single nucleotide polymorphisms (SNPs). Results: Mean admixture estimates obtained using ABO*O and ABO*A alleles and AIMs were 35, 47% and 48% respectively. There was concordance in estimates, with the exception of the admixture based on ABO*O allele and AIMs. Conclusions: In Chile, Amerindian admixture estimates obtained using ABO*A could be used as an alternative to AIMs in justified cases provided the sample size is reasonably large.

Keywords : American Native; Continental Ancestry Group; Chile, ABO Blood-Group System; Indians, South American.

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