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Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

ROCHA, Gladys; SIERRALTA, Walter  y  VALLADARES, Luis. 27- Hydroxycholesterol reverses estradiol induced inhibition of platelet aggregation in postmenopausal women. Rev. méd. Chile [online]. 2016, vol.144, n.11, pp.1377-1381. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872016001100002.

Background: The decline of estrogen levels increases cardiovascular risk in women. Platelets express estrogen receptors and 17β-estradiol- (E2) can produce a protective effect on thrombus formation. The hydroxylation of cholesterol generates several sterols and 27-hydroxycholesterol (27HC) predominates in circulation. Aim: To evaluate the effect of 27HC as an endogenous antagonist of the anti-aggregating properties of E2 in platelets of postmenopausal women. Material and Methods: Platelet function of postmenopausal women was evaluated ex-vivo. Platelets pre-incubated with 27HC in the presence or absence of E2, were stimulated with collagen. Aggregation was evaluated using turbidimetry using a Chrono-log aggregometer. Results: Collagen-stimulated platelet aggregation was significantly inhibited by E2. The inhibitory effect of E2 on collagen-stimulated platelet aggregation was significantly reversed in the presence of 27HC. Conclusions: The suppressive effect of E2 on platelet aggregation is inhibited by 27HC, which could contribute to increase cardiovascular risk in postmenopausal women.

Palabras clave : Estradiol; 27-hydroxycholesterol; Platelet Aggregation; Postmenopause.

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