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Revista médica de Chile

Print version ISSN 0034-9887

Abstract

GONZALEZ R, Pablo; HUDSON A, Lorena; BASAEZ M, Esteban  and  MIRANDA C, Marcelo. Autoimmune encephalitis induced by antibodies against GABA-A receptor. Rev. méd. Chile [online]. 2016, vol.144, n.11, pp.1491-1493. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872016001100017.

Among autoimmune encephalitides, a prevalent group are those associated with antibodies against the N-Methyl-D-aspartate receptor, which present with behavior abnormalities, psychosis, seizures and abnormal movements. A new variant, mediated by antibodies against the GABA-A receptor, was recen­tly described. We report a 66-years-old female with this form of encephalitis whose main manifestation was the presence of severe seizures leading to status epilepticus. The patient had a good response to immunomodulatory therapy with intravenous methylprednisolone, azathioprine and anticonvulsants. The laboratory tests initially detected anti-thyroid peroxidase antibodies which lead to the misdiagnosis of Hashimoto Encephalitis, which was ruled out after the detection of antibodies against GABA-A receptor. No malignancy was detected.

Keywords : Autoimmune Diseases; Encephalitis; Receptors, GABA.

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