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Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

CIORTEA, Răzvan et al. GRP78 levels, regional fat distribution and endometrial cáncer. Rev. méd. Chile [online]. 2016, vol.144, n.12, pp.1577-1583. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872016001200009.

Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance. Aim: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer. Material and methods: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured. Results: GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p<0.01). Gynoid fat had a negative correlation with plasma GRP78 levels (p<0.01). Conclusions: GRP78 levels are associated with the distribution of adipose tissue and are higher in patients with endometrial cancer.

Palabras clave : Adipose Tissue; Endometrial Neoplasms; Obesity; Endoplasmic Reticulum Stress.

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