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Revista médica de Chile

Print version ISSN 0034-9887

Abstract

ROSSEL, Víctor et al. Galectina-3: experiencia en pacientes chilenos con diagnóstico de insuficiencia cardíaca descompensada. Rev. méd. Chile [online]. 2017, vol.145, n.6, pp.734-740. ISSN 0034-9887.  http://dx.doi.org/10.4067/s0034-98872017000600734.

Background:

Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF). Aim: To measure Gal-3 at the moment of discharge in patients hospitalized for HF and its association with different variables.

Material and Methods:

Patients hospitalized for decompensated HF from four hospitals between August 2014 and March 2015, were included. Demographic, clinical and laboratory variables were recorded at the time of admission. At discharge, a blood sample was withdrawn to measure Gal-3 and brain natriuretic propeptide (Pro-BNP). Patients were separated in two groups, according to the level of Gal-3 (using a cutoff value of 17.8 ng/mL), comparing clinical and laboratory values between groups.

Results:

We included 52 patients with HF aged 70 ± 17 years (42% females). Functional capacity was III-IV in 46% of patients and the ejection fraction was 34.9 ± 13.4%. Pro-BNP values at discharge were 5,323 ± 8,665 pg/mL. Gal-3 values were 23.8 ± 16.6 ng/mL. Sixty percent of patients had values over 17.8 ng/mL. Those with elevated Gal-3 levels were older (75 ±16 and 62 ± 15 years, respectively, p = 0.025) and were hypertensive in a higher proportion (90.5% and 57.1% respectively, p = 0.021).

Conclusions:

In patients hospitalized for HF, Gal-3 levels are higher in older and hypertensive subjects.

Keywords : Biomarkers; Galectin-3; Heart Failure.

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