SciELO - Scientific Electronic Library Online

 
vol.146 número4Licencia médica psiquiátrica: revisión de los efectos positivos y negativos del reposoInternación psiquiátrica involuntaria. Antecedentes, reflexiones y desafíos índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Revista médica de Chile

versión impresa ISSN 0034-9887

Resumen

ALEMAN, Larissa  y  GUERRERO, Julia. Sepsis hyperglycemia in the ICU: from the mechanism to the clinic. Rev. méd. Chile [online]. 2018, vol.146, n.4, pp.502-510. ISSN 0034-9887.  http://dx.doi.org/10.4067/s0034-98872018000400502.

Stress hyperglycemia is frequently diagnosed in septic patients in critical care units (ICU) and it is associated with greater illness severity and higher morbimortality rates. In response to an acute injury, high levels of counterregulatory hormones such as glucocorticoids and catecholamines are released causing increased hepatic gluconeogenesis and insulin resistance. Furthermore, during sepsis, proinflammatory cytokines also participate in the pathogenesis of this phenomenon. Septic patients represent a subtype of the critical ill patients in the ICU: this metabolic disarrangement management strategies and insulin therapy recommendations had been inconsistent. In this article, we describe the pathophysiological mechanisms of stress hyperglycemia in critical patients including the action of hormones, inflammatory cytokines and tissue resistance to insulin. In addition, we analyzed the main published studies for the treatment of acute hyperglycemia in critical patients.

Palabras clave : Critical Illness; Hyperglycemia; Intensive Care Units.

        · texto en Español     · Español ( pdf )