SciELO - Scientific Electronic Library Online

 
vol.146 issue6Emergency endovascular management of ischemic stroke. Experience in 104 patientsVerbal and physical abuse towards health care workers in emergency services author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Revista médica de Chile

Print version ISSN 0034-9887

Abstract

PETERMANN, Fanny et al. Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults. Rev. méd. Chile [online]. 2018, vol.146, n.6, pp.717-726. ISSN 0034-9887.  http://dx.doi.org/10.4067/s0034-98872018000600717.

Background:

Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity.

Aim:

To investigate the association of FTO gene with adiposity markers in Chilean adults.

Material and Methods:

409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio.

Results:

A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score.

Conclusions:

This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.

Keywords : Adiposity; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Genotype; Obesity.

        · text in Spanish     · Spanish ( pdf )