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Revista médica de Chile

versão impressa ISSN 0034-9887

Resumo

PETERMANN, Fanny et al. Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults. Rev. méd. Chile [online]. 2018, vol.146, n.6, pp.717-726. ISSN 0034-9887.  http://dx.doi.org/10.4067/s0034-98872018000600717.

Background:

Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity.

Aim:

To investigate the association of FTO gene with adiposity markers in Chilean adults.

Material and Methods:

409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio.

Results:

A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score.

Conclusions:

This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.

Palavras-chave : Adiposity; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Genotype; Obesity.

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