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Revista médica de Chile

Print version ISSN 0034-9887

Abstract

VILLAGRAN, Marcelo et al. Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena. Rev. méd. Chile [online]. 2018, vol.146, n.11, pp.1252-1260. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872018001101252.

Background:

Fat-mass-associated-gene (FTO) is associated with higher energy intake and specific food preferences.

Aim:

To investigate the association of the FTO genotype with energy intake, macronutrient and alcohol consumption.

Material and Methods:

Four hundred and nine participants of the GENADIO (Genes, Environment, Diabetes and Obesity) study were included. Energy intake, macronutrient and alcohol consumption were the outcomes of interest. The association of FTO (rs9939609) genotype with these outcomes was investigated using linear regression analyses, adjusting for confounding variables.

Results:

After adjusting for socio-demographic factors, being a carrier of the risk allele for the FTO gene was associated with a higher energy intake (173 kcal per each extra copy of the risk variant [95% confidence intervals (CI): 45; 301], (P = 0.008). After adjusting for lifestyle factors and body mass index, the association was slightly attenuated but remained significant (144 kcal [95% CI: 14; 274], p = 0.030).

Conclusions:

The FTO genotype is associated with a higher energy intake.

Keywords : Alpha-Ketoglutarate-Dependent Dioxygenase; Diet; Energy Intake; FTO; Genotype.

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