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Revista médica de Chile

Print version ISSN 0034-9887


LOPEZ-VIDAL, Hernán et al. Autoimmune hemolytic anemia. Review of 43 cases. Rev. méd. Chile [online]. 2019, vol.147, n.7, pp.836-841. ISSN 0034-9887.


Autoimmune hemolytic anemia (AIHA) is an uncommon disease. In its presentation, it can be severe and even lethal. There is only one clinical report concerning this pathology in Chile.


To describe the clinical characteristics and evolution of adult AIHA inpatients.

Materials and Methods:

Retrospective review of clinical records of adult AIHA inpatients between January 2010 and June 2018 was done. Demographic, clinical, laboratory and therapeutic information was analyzed. A descriptive, analytical and survival analysis was performed.


Forty-three adult patients diagnosed with AHIA were hospitalized in a period of 8 years. Median age was 63 years (range 22-86 years), mostly women (72%). Warm antibodies were detected in 36 cases (84%) and cold antibodies in seven. Seventy two percent of the patients had an underlying cause, and 58% were secondary to lymphoproliferative neoplasms. All patients except two, received steroids as initial treatment, with response in 37 (90%) of them. Three refractory patients received rituximab, with response in all of them, and relapse in one. Median follow-up was 38 months (range 2-98 months). Five year overall survival was 72%.


AHIA in adults inpatients is a heterogeneous disease, mainly due to warm antibodies, and to secondary etiology.

Keywords : Autoimmune Diseases; Autoantibodies; Anemia, Hemolytic, Autoimmune; Rituximab.

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