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Revista médica de Chile

Print version ISSN 0034-9887

Abstract

LOPEZ-VIDAL, Hernán et al. Autoimmune hemolytic anemia. Review of 43 cases. Rev. méd. Chile [online]. 2019, vol.147, n.7, pp.836-841. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872019000700836.

Background:

Autoimmune hemolytic anemia (AIHA) is an uncommon disease. In its presentation, it can be severe and even lethal. There is only one clinical report concerning this pathology in Chile.

Objective:

To describe the clinical characteristics and evolution of adult AIHA inpatients.

Materials and Methods:

Retrospective review of clinical records of adult AIHA inpatients between January 2010 and June 2018 was done. Demographic, clinical, laboratory and therapeutic information was analyzed. A descriptive, analytical and survival analysis was performed.

Results:

Forty-three adult patients diagnosed with AHIA were hospitalized in a period of 8 years. Median age was 63 years (range 22-86 years), mostly women (72%). Warm antibodies were detected in 36 cases (84%) and cold antibodies in seven. Seventy two percent of the patients had an underlying cause, and 58% were secondary to lymphoproliferative neoplasms. All patients except two, received steroids as initial treatment, with response in 37 (90%) of them. Three refractory patients received rituximab, with response in all of them, and relapse in one. Median follow-up was 38 months (range 2-98 months). Five year overall survival was 72%.

Conclusion:

AHIA in adults inpatients is a heterogeneous disease, mainly due to warm antibodies, and to secondary etiology.

Keywords : Autoimmune Diseases; Autoantibodies; Anemia, Hemolytic, Autoimmune; Rituximab.

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