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Revista médica de Chile

versión impresa ISSN 0034-9887


CORTES, VÍCTOR  y  SANTOS, JOSÉ LUIS. Clinical presentation and treatment of primary lipodystrophies. Rev. méd. Chile [online]. 2019, vol.147, n.11, pp.1449-1457. ISSN 0034-9887.

Lipodystrophies are a heterogeneous group of syndromes defined by a severe reduction of the adipose tissue. These can be congenital or acquired. Anatomically, they can be partial or generalized. The etiology of several lipodystrophies is well known. However, the cause of many others remains unknown. The commonest lipodystrophy worldwide is secondary to highly active anti-retroviral therapy in HIV-infected patients. By contrast, primary lipodystrophies (those not associated to any known disease or condition) are much less common and represent a diagnostic challenge. The major complications of lipodystrophies are metabolic, often resulting in severe insulin resistance, diabetes and dyslipidemia. No cure is available for lipodystrophies but the supplementation with recombinant leptin potently controls the metabolic abnormalities when there is a leptin deficiency. Herein, we review the clinical presentation, diagnostic process and therapeutic principles of the main primary lipodystrophy syndromes.

Palabras clave : Adipose Tissue; Diabetes Melllitus; Insulin Resistance; Leptin; Lipodystrophy.

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