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Revista médica de Chile

Print version ISSN 0034-9887


ARANEDA, PATRICIA et al. Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico. Rev. méd. Chile [online]. 2019, vol.147, n.11, pp.1487-1490. ISSN 0034-9887.


The 2016 WHO Classification of Tumours of the Central Nervous System incorporates a new diagnostic entity: the mutant diffuse midline glioma H3K27, a tumor with a characteristic location and special molecular biology. We report the case of a 51-year-old male patient with progressive diplopia. The imaging study showed a mesencephalic tumor; the stereotacic biopsy disclosed an Anaplastic Astrocytoma Isocitrate dehydrogenase (IDH) wild type. The molecular study concludes H3K27 mutation. The patient was treated with radiotherapy with concurrent and adjuvant chemotherapy (temozolomide) with partial recovery of the diplopia.

Keywords : Astrocytoma; Glioma; Histones.

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