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Revista médica de Chile

Print version ISSN 0034-9887


MIRANDA C., MARCELO  and  BUSTAMANTE C., M. LEONOR. Hierro intravenoso en la terapia del síndrome de piernas inquietas. Rev. méd. Chile [online]. 2019, vol.147, n.12, pp.1569-1571. ISSN 0034-9887.

Restless legs syndrome (RLS) may severely affect the quality of life of patients. A deficient iron incorporation into the central nervous system has an important role in the pathophysiology of RLS. Severely affected patients may not respond to current therapeutic options. We report a preliminary experience with five patients with severe RLS and low serum ferritin levels who did not improve with oral iron. All were treated with 1 g of intravenous iron carboxymaltose. They experienced a marked improvement in symptoms, evident even during the first week of therapy that had persistent after up to two years of follow-up. A significant change in the RLS severity scale was observed after intravenous iron. Serum ferritin levels increased in all of them. Intravenous iron could be a therapeutic option for patients with severe RLS.

Keywords : Iron: Restless Legs Syndrome; Therapeutics.

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