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Revista médica de Chile

Print version ISSN 0034-9887

Abstract

SANCHEZ, César et al. Survival rates of advanced estrogen-receptor positive breast cancer. Analysis of 211 cases. Rev. méd. Chile [online]. 2020, vol.148, n.9, pp.1233-1238. ISSN 0034-9887.  http://dx.doi.org/10.4067/S0034-98872020000901233.

Background:

About 80% of breast cancer (BC) cases express estrogen receptor (ER), which has been correlated with good prognosis and response to estrogen deprivation

Aim:

To characterize ER positive advanced BC (ABC) patients treated at our institution assessing the impact of clinical pre-sentation (stage IV, de novo disease at diagnosis versus systemic recurrence) and BC subtype on survival rates.

Material and Methods:

We evaluated 211 ER+ advanced BC (ABC) patients, treated between 1997 and 2017.

Results:

The median overall survival (OS) was 37 months. Median OS for the period 1997/2006 and 2007/2017 were 33 and 42 months, respectively (p = 0.47). Luminal A, ABC stage IV disease at diagnosis displayed better OS rates than Luminal B stage IV tumors (100 and 32 months respectively, p < 0.01).

Conclusions:

Clinical presentation (stage IV vs. systemic recurrence) and tumor subtype are key determinants of OS in ABC.

Keywords : Breast Neoplasms; Neoplasm Metastasis; Prognosis; Receptors, Estrogen.

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