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Archivos de medicina veterinaria

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DE NARDI, AB et al. Cyclooxigenase-2 expression in primary metastatic and non metastatic canine mammarian carcinomas. Arch. med. vet. [online]. 2013, vol.45, n.3, pp.311-316. ISSN 0301-732X.

The aim of this study was to detect the expression of ciclooxigenase-2 (COX-2) in metastatic primary carcinoma and non metastatic carcinoma, taking into consideration the relation between COX-2 and the progression of cancer. Evaluation of the COX-2 expression was achieved by immunohistochemistry analysis, using the primary polyclonal antibody anti-PGHS-2, clone PG 27, (Oxford Biomedical Research). The number of marked cells by the COX-2 antibody was higher (P < 0.001) in the metastatic primary carcinoma (81.25%) than non-metastatic (60.3%). There was a positive correlation between the number of labeled cells.

Keywords : cancer; mammary neoplasm; ciclooxigenase-2; dogs.

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