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Boletín de la Sociedad Chilena de Química

versão impressa ISSN 0366-1644

Resumo

LOYOLA, LUIS A. et al. AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY. Bol. Soc. Chil. Quím. [online]. 2001, vol.46, n.1, pp.9-13. ISSN 0366-1644.  http://dx.doi.org/10.4067/S0366-16442001000100003.

In addition to azorellanol a new diterpenoid 7-deacetylazorellanol, has been isolated from the aerial parts of Laretia acaulis (Cav.) Gill et Hook (Umbelliferae). Its structure was based on spectroscopic comparison with azorellanol and chemical grounds. Azorellanol and 7-deacetylazorellanol showed marked inhibitor activity against trophozoites of protozoan parasite Toxoplasma gondii. The 50 % inhibitory dose for azorellanol was calculated in 54 mM and for 7-deacetylazorellanol was 42 mM.

Palavras-chave : Laretia acaulis; diterpenoids; azorellanol; 7-deacetylazorellanol; Toxoplasma gondii.

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